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Pathology

OMS and Other Dental Specialists

Residents

SSOD40 - Pathologic Lesions Secreting Beta-hCG

On-demand
CE: 1.0 CDE/CME
On-demand<br><i>On-demand session available beginning Sept. 28.</i>
Human chorionic gonadotropin is a hormone secreted by the placenta and trophoblastic neoplasms. It is a marker for pregnancy and trophoblastic disease. Its free beta subunit also is secreted by some non-trophoblastic epithelial malignancies. In fact, beta-hCG secretion by some of these neoplasms is linked with more aggressive behavior and poorer prognosis. In vitro, beta-hCG increases growth of cancer cell lines in a dose-dependent manner. It is hypothesized that in the setting of epithelial tumors, beta-hCG acts as an autocrine/paracrine growth-stimulating growth factor that inhibits the TGF-beta apoptosis signaling pathway.

These types of tumors have been seldom reported in gnathic bones. A recent diagnosis of beta-hCG secreting giant cell tumor of the mandible in a 16-year-old female patient prompted the presenters to delve deeper into this class of lesions. The presenters will present their findings in this knowledge update.

Learning Objectives:

At the conclusion of this presentation, participants should be able to:
  1. Appreciate and acknowledge that certain non-trophoblastic epithelial neoplasms may secrete beta-hCG and that some of these lesions may be present in gnathic bones.
  2. Acknowledge the broad spectrum of pathologic entities that have been reported to secrete beta-hCG.
  3. Comprehend the use of serum beta-hCG as a screening, disease activity monitoring and prognostication tool.